The Caloosahatchee River was once a major transportation artery for the Calusa Indians and other early settlers to Fort Myers. Today powerboats and sailboats traverse the 67-mile-long river, which is an important part of the OCWW.

The river is wide enough to accommodate everyone including the abundant wildlife. The Caloosahatchee River and its meandering tributaries are bordered by lush, towering leather ferns, stately oaks dripping with moss and verdant vegetation along every shore.